mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
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چکیده
منابع مشابه
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متن کاملmTORC1 stimulates nucleotide synthesis through both transcriptional and post-translational mechanisms
Background Cellular growth signals stimulate anabolic processes. The mechanistic target of rapamycin (mTOR), as part of mTORC1, is a protein kinase that senses growth signals to regulate anabolic growth and proliferation. mTORC1 stimulates protein synthesis through effects on mRNA translation and ribosome biogenesis [1]. mTORC1 signaling also promotes de novo lipid and sterol synthesis through ...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2017
ISSN: 1535-6108
DOI: 10.1016/j.ccell.2017.09.013